SARS-CoV-2 elicits robust adaptive immune responses regardless of disease severity.

ABSTRACT:

Background

The SARS-CoV-2 pandemic currently prevails worldwide. To understand the immunological signature of SARS-CoV-2 infections and aid the search and evaluation of new treatment modalities and vaccines, comprehensive characterization of adaptive immune responses towards SARS-CoV-2 is needed.

Methods

We included 203 recovered SARS-CoV-2 infected patients in Denmark between April 3^rd and July 9^th 2020, at least 14 days after COVID-19 symptom recovery. The participants had experienced a range of disease severities from asymptomatic to severe. We collected plasma, serum and PBMC's for analysis of SARS-CoV-2 specific antibody response by Meso Scale analysis including other coronavirus strains, ACE2 competition, IgA ELISA, pseudovirus neutralization capa

SUBMITTER: Nielsen SS 

PROVIDER: S-EPMC8176920 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature