Immunohistochemical expression of substance P in breast cancer and its association with prognostic parameters and Ki-67 index.

ABSTRACT:

Background

The neuropeptide substance P is a potential biomarker and therapeutic target in cancer. The main objectives of this study were to investigate the expression level of substance P in different breast cancer molecular subtypes and identify its association with clinicopathological parameters of patients and with Ki-67 index.

Methods

A retrospective analysis was performed for a total of 164 paraffin-embedded breast cancer tissue samples [42 Her2/neu-enriched, 40 luminal A, 42 luminal B (triple-positive) and 40 triple negative subtypes]. The tissue microarray slides containing specimens were used to determine the expression of substance p and Ki-67 by immunohistochemical staining.

Results

The mean age of the cohort was 51.35 years. Twenty two percent of cases had

SUBMITTER: Al-Keilani MS 

PROVIDER: S-EPMC8177477 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature