Molecular imaging can identify the location to perform a frozen biopsy during intraoperative frozen section consultation.

ABSTRACT:

Background

Intraoperative frozen section (FS) consultation is an important tool in surgical oncology that suffers from sampling error because the pathologist does not always know where to perform a biopsy of the surgical specimen. Intraoperative molecular imaging is a technology used in the OR to visualize lesions during surgery. We hypothesized that molecular imaging can address this pathology challenge in FS by visualizing the cancer cells in the specimen in the pathology suite. Here, we report the development and validation of a molecular-imaging capable cryostat called Smart-Cut.

Methods

A molecular imaging capable cryostat prototype was developed and tested using a murine model. Tumors grown in mice were targeted with a NIR contrast agent, indocyanine green (ICG), via t

SUBMITTER: Bryski MG 

PROVIDER: S-EPMC8177495 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature