Association of the CFTR gene with asthma and airway mucus hypersecretion.

ABSTRACT:

Introduction

Asthma with airway mucus hypersecretion is an inadequately characterized variant of asthma. While several studies have reported that hypersecreting patients may carry genetic variants in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, many of those studies have been questioned for their numerous limitations and contradictory results.

Objectives

(1) To determine the presence of genetic variants of the CFTR gene in patients with asthma with and without airway mucus hypersecretion. (2) To identify the clinical, inflammatory and functional characteristics of the asthma phenotype with airway mucus hypersecretion.

Method

Comparative multicentre cross-sectional descriptive study that included 100 patients with asthma (39 hypersecretors and 6

SUBMITTER: Crespo-Lessmann A 

PROVIDER: S-EPMC8177500 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature