Urinary polycyclic aromatic hydrocarbon metabolites and mortality in the United States: A prospective analysis.

ABSTRACT:

Background

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous organic compounds associated with chronic disease in epidemiologic studies, though the contribution of PAH exposure on fatal outcomes in the U.S. is largely unknown.

Objectives

We investigated urinary hydroxylated PAH metabolites (OH-PAHs) with all-cause and cause-specific mortality in a representative sample of the U.S. population.

Methods

Study participants were ≥20 years old from the National Health and Nutrition Examination Survey 2001-2014. Concentrations (nmol/L) of eight OH-PAHs from four parent PAHs (naphthalene, fluorene, phenanthrene, pyrene) were measured in spot urine samples at examination. We identified all-cause, cancer-specific, and cardiovascular-specific deaths through 2015 using the N

SUBMITTER: Patel AP 

PROVIDER: S-EPMC8177506 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature