Mimicking SIV chimpanzee viral evolution toward HIV-1 during cross-species transmission.

ABSTRACT: HIV-1 evolved from SIV during cross-species transmission events, though viral genetic changes are not well understood. Here, we studied the evolution of SIVcpzLB715 into HIV-1 Group M using humanized mice. High viral loads, rapid CD4⁺ T-cell decline, and non-synonymous substitutions were identified throughout the viral genome suggesting viral adaptation.

SUBMITTER: Schmitt K 

PROVIDER: S-EPMC8177655 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature