The Cryo-EM Effect: Structural Biology of Neurodegenerative Disease Aggregates.

ABSTRACT: Neurogenerative diseases are characterized by diverse protein aggregates with a variety of microscopic morphologic features. Although ultrastructural studies of human neurodegenerative disease tissues have been conducted since the 1960s, only recently have near-atomic resolution structures of neurodegenerative disease aggregates been described. Solid-state nuclear magnetic resonance spectroscopy and X-ray crystallography have provided near-atomic resolution information about in vitro aggregates but pose logistical challenges to resolving the structure of aggregates derived from human tissues. Recent advances in cryo-electron microscopy (cryo-EM) have provided the means for near-atomic resolution structures of tau, amyloid-β (Aβ), α-synuclein (α-syn), and transactive response element DNA-bi

SUBMITTER: Creekmore BC 

PROVIDER: S-EPMC8177849 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature