Dissociative and analgesic properties of ketamine are independent and unaltered by sevoflurane general anesthesia.

ABSTRACT:

Introduction

Ketamine, an anesthetic adjunct, is routinely administered as part of a balanced general anesthetic technique. We recently showed that the acute analgesic and dissociation properties of ketamine are separable to suggest that distinct neural circuits underlie these states.

Objective

We aimed to study whether this finding is robust to the substantial neural circuit alterations associated with general anesthesia.

Methods

We conducted a single-site, open-label, randomized controlled, cross-over study of sevoflurane and sevoflurane-plus-ketamine (SK) general anesthesia in healthy subjects (n = 12). Before and after general anesthesia, we assessed precalibrated cuff pain intensity and nociceptive pain quality as well as dissociation using the Clinician-Administ

SUBMITTER: Hahm EY 

PROVIDER: S-EPMC8177870 | biostudies-literature | 2021 Jul-Aug

REPOSITORIES: biostudies-literature