Spontaneous neural synchrony links intrinsic spinal sensory and motor networks during unconsciousness.

ABSTRACT: Non-random functional connectivity during unconsciousness is a defining feature of supraspinal networks. However, its generalizability to intrinsic spinal networks remains incompletely understood. Previously, Barry et al., 2014 used fMRI to reveal bilateral resting state functional connectivity within sensory-dominant and, separately, motor-dominant regions of the spinal cord. Here, we record spike trains from large populations of spinal interneurons in vivo in rats and demonstrate that spontaneous functional connectivity also links sensory- and motor-dominant regions during unconsciousness. The spatiotemporal patterns of connectivity could not be explained by latent afferent activity or by populations of interconnected neurons spiking randomly. We also document connection latencies compat

SUBMITTER: McPherson JG 

PROVIDER: S-EPMC8177891 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature