Differential dopaminergic modulation of spontaneous cortico-subthalamic activity in Parkinson's disease.

ABSTRACT: Pathological oscillations including elevated beta activity in the subthalamic nucleus (STN) and between STN and cortical areas are a hallmark of neural activity in Parkinson's disease (PD). Oscillations also play an important role in normal physiological processes and serve distinct functional roles at different points in time. We characterised the effect of dopaminergic medication on oscillatory whole-brain networks in PD in a time-resolved manner by employing a hidden Markov model on combined STN local field potentials and magnetoencephalography (MEG) recordings from 17 PD patients. Dopaminergic medication led to coherence within the medial and orbitofrontal cortex in the delta/theta frequency range. This is in line with known side effects of dopamine treatment such as deteriorated execu

SUBMITTER: Sharma A 

PROVIDER: S-EPMC8177893 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature