Long-term macrolide therapy for chronic obstructive pulmonary disease: a population-based time series analysis.

ABSTRACT:

Background

Macrolides are recommended as an adjunctive treatment for patients with moderate to severe chronic obstructive pulmonary disease (COPD) who experience recurrent exacerbations. The objective of this study was to examine temporal trends in the provision of long-term macrolide therapy, specifically before and after publication of the landmark MACRO trial in August 2011 showing efficacy of macrolides for this indication.

Methods

We performed an interrupted time series analysis using population-level health administrative data. The study cohort consisted of all Ontario residents who had COPD, were using at least 1 long-acting inhaler, and were aged 65 years and older between Apr. 1, 2004, and Mar. 31, 2018. We compared the baseline characteristics of eligible patients

SUBMITTER: Yan M 

PROVIDER: S-EPMC8177912 | biostudies-literature | 2021 Apr-Jun

REPOSITORIES: biostudies-literature