Association of Helicobacter pylori Infection and Host Cytokine Gene Polymorphism with Gastric Cancer.

ABSTRACT: The global cancer burden of new cases of various types rose with millions of death in 2018. Based on the data extracted by GLOBOCAN 2018, gastric cancer (GC) is the third leading cause of mortality related to cancer across the globe. Carcinogenic or oncogenic infections associated with Helicobacter pylori (Hp) are regarded as one of the essential risk factors for GC development. It contributes to the increased production of cytokines that cause inflammation prior to their growth in the host cells. Hp infections and specific types of polymorphisms within the host cells encoding cytokines are significant contributors to the host's increased susceptibility in terms of the development of GC. Against the backdrop of such an observation is that only a small portion of the cells infected c

SUBMITTER: Zeyaullah M 

PROVIDER: S-EPMC8177986 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature