Metabolites as predictive biomarkers for Trypanosoma cruzi exposure in triatomine bugs.

ABSTRACT: Trypanosoma cruzi, the causative agent of Chagas disease (American trypanosomiasis), colonizes the intestinal tract of triatomines. Triatomine bugs act as vectors in the life cycle of the parasite and transmit infective parasite stages to animals and humans. Contact of the vector with T. cruzi alters its intestinal microbial composition, which may also affect the associated metabolic patterns of the insect. Earlier studies suggest that the complexity of the triatomine fecal metabolome may play a role in vector competence for different T. cruzi strains. Using high-resolution mass spectrometry and supervised machine learning, we aimed to detect differences in the intestinal metabolome of the triatomine Rhodnius prolixus and predict whether the insect had been expo

SUBMITTER: Eberhard FE 

PROVIDER: S-EPMC8178018 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature