α-Tocopherol Stereoisomer Profiles in Matched Human Maternal and Umbilical Cord Plasma.

ABSTRACT:

Background

α-Tocopherol (αT) is essential for fetal development. One study has shown that the human placenta preferentially transfers the natural stereoisomer, RRR-αT. But prenatal supplements generally contain synthetic αT (S-αT).

Objectives

We aimed to determine if umbilical cord plasma is enriched for RRR-αT in racially diverse neonates from both uncomplicated and complicated pregnancies and if cord RRR-αT enrichment is impacted by maternal αT stereoisomer profile.

Methods

We measured αT and αT stereoisomers in plasma from a randomly selected subset of 66 predominantly black and Hispanic maternal-fetal pairs from the Camden Study involving control (n = 28) and complicated pregnancies (n = 38). We collected maternal plasma at study

SUBMITTER: Kuchan MJ 

PROVIDER: S-EPMC8178107 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature