Ontology highlight
ABSTRACT:
SUBMITTER: Pikman Y
PROVIDER: S-EPMC8178162 | biostudies-literature | 2021 Jun
REPOSITORIES: biostudies-literature
Pikman Yana Y Tasian Sarah K SK Sulis Maria Luisa ML Stevenson Kristen K Blonquist Traci M TM Apsel Winger Beth B Cooper Todd M TM Pauly Melinda M Maloney Kelly W KW Burke Michael J MJ Brown Patrick A PA Gossai Nathan N McNeer Jennifer L JL Shukla Neerav N NN Cole Peter D PD Kahn Justine M JM Chen Jing J Barth Matthew J MJ Magee Jeffrey A JA Gennarini Lisa L Adhav Asmani A AA Clinton Catherine M CM Ocasio-Martinez Nicole N Gotti Giacomo G Li Yuting Y Lin Shan S Imamovic Alma A Tognon Cristina E CE Patel Tasleema T Faust Haley L HL Contreras Cristina F CF Cremer Anjali A Cortopassi Wilian A WA Garrido Ruiz Diego D Jacobson Matthew P MP Dharia Neekesh V NV Su Angela A Robichaud Amanda L AL Saur Conway Amy A Tarlock Katherine K Stieglitz Elliot E Place Andrew E AE Puissant Alexandre A Hunger Stephen P SP Kim Annette S AS Lindeman Neal I NI Gore Lia L Janeway Katherine A KA Silverman Lewis B LB Tyner Jeffrey W JW Harris Marian H MH Loh Mignon L ML Stegmaier Kimberly K
Cancer discovery 20210209 6
Despite a remarkable increase in the genomic profiling of cancer, integration of genomic discoveries into clinical care has lagged behind. We report the feasibility of rapid identification of targetable mutations in 153 pediatric patients with relapsed/refractory or high-risk leukemias enrolled on a prospective clinical trial conducted by the LEAP Consortium. Eighteen percent of patients had a high confidence Tier 1 or 2 recommendation. We describe clinical responses in the 14% of patients with ...[more]