Clinical and Biological Subtypes of B-cell Lymphoma Revealed by Microenvironmental Signatures.

ABSTRACT: Diffuse large B-cell lymphoma (DLBCL) is a biologically and clinically heterogeneous disease. Transcriptomic and genetic characterization of DLBCL has increased the understanding of its intrinsic pathogenesis and provided potential therapeutic targets. However, the role of the microenvironment in DLBCL biology remains less understood. Here, we performed a transcriptomic analysis of the microenvironment of 4,655 DLBCLs from multiple independent cohorts and described four major lymphoma microenvironment categories that associate with distinct biological aberrations and clinical behavior. We also found evidence of genetic and epigenetic mechanisms deployed by cancer cells to evade microenvironmental constraints of lymphoma growth, supporting the rationale for implementing DNA hypomethylating

SUBMITTER: Kotlov N 

PROVIDER: S-EPMC8178179 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature