Sex differences in in vivo tau neuropathology in a multiethnic sample of late middle-aged adults.

ABSTRACT: It is unclear whether women have higher brain tau pathology. The objective of this study was to examine whether women have higher tau burden than men, and whether tau differences are independent of amyloid β (Aβ) burden. We conducted a cross-sectional analysis of a multiethnic sample of 252 nondemented late middle-aged (mean age: 64.1 years) adults with tau and amyloid Positron Emission Tomography (PET) data. Tau burden was measured as global standardized uptake value ratio (SUVR) in the middle/inferior temporal gyri and medial temporal cortex with ¹⁸F-MK-6240 PET. Aβ was measured as global SUVR with ¹⁸F-Florbetaben PET. Women had higher middle/inferior temporal gyri tau SUVR compared to men. However, no sex differences in the medial temporal cortex were observed. Wom

SUBMITTER: Palta P 

PROVIDER: S-EPMC8178209 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature