Amino acid-based H₂S donors: N-thiocarboxyanhydrides that release H₂S with innocuous byproducts.

ABSTRACT: A library of N-thiocarboxyanhydrides (NTAs) derived from natural amino acids with benign byproducts and controlled H2S-release kinetics is reported. Minimal acute in vitro toxicity was observed in multiple cell lines, while longer-term toxicity in cancer cells was observed, with slow-releasing donors exhibiting the greatest cytotoxic effects.

SUBMITTER: Kaur K 

PROVIDER: S-EPMC8178226 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature