Potent germline-like monoclonal antibodies: rapid identification of promising candidates for antibody-based antiviral therapy.

ABSTRACT: In recent years, fully human monoclonal antibodies (mAbs) are making up an increasing share of the pharmaceutical market. However, to improve affinity and efficacy of antibodies, many somatic hypermutations could be introduced during affinity maturation, which cause several issues including safety and efficacy and limit their application in clinic. Here, we propose a special class of human mAbs with limited level of somatic mutations, referred to as germline-like mAbs. Remarkably, germline-like mAbs could have high affinity and potent neutralizing activity in vitro and in various animal models, despite lacking of extensive affinity maturation. Furthermore, the germline nature of these mAbs implies that they exhibit lower immunogenicity and can be elicited relatively fast in vivo<

SUBMITTER: Zhu X 

PROVIDER: S-EPMC8178282 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature