Kidney injury molecule-1 inhibits metastasis of renal cell carcinoma.

ABSTRACT: Metastasis is present in approximately 30% of patients diagnosed with renal cell carcinoma (RCC) and is associated with a 5-year survival rate of < 15%. Kidney injury molecule 1 (KIM-1), encoded by the HAVCR1 gene, is a proximal tubule cell-surface glycoprotein and a biomarker for early detection of RCC, but its pathophysiological significance in RCC remains unclear. We generated human and murine RCC cell lines either expressing or lacking KIM-1, respectively, and compared their growth and metastatic properties using validated methods. Surprisingly, KIM-1 expression had no effect on cell proliferation or subcutaneous tumour growth in immune deficient (Rag1^-/-) Balb/c mice, but inhibited cell invasion and formation of lung metastasis in the same model. Further, we show that the i

SUBMITTER: Lee JC 

PROVIDER: S-EPMC8178330 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature