Parathyroid Hormone Concentrations in Maintenance Hemodialysis: Longitudinal Evaluation of Intact and Biointact Assays.

ABSTRACT:

Rationale & objective

Management of chronic kidney disease mineral and bone disorder requires parathyroid hormone (PTH) concentrations. "Biointact" PTH immunoassays detect "whole" PTH (wPTH), whereas "intact" immunoassays measure PTH plus PTH fragments (iPTH). We aimed to determine whether longitudinal changes in PTH concentrations can be evaluated using biointact and intact immunoassays alike.

Study design

Open noninterventional longitudinal cohort study.

Setting & participants

PTH concentrations were measured quarterly up to 5 times in 102 hemodialysis patients.

Predictors & tests compared

Age, sex, phosphate levels, and others as clinical predictors for PTH trend. Tests compared were iPTH immunoassays from Siemens and Roche and wPTH immunoassays from Roche a

SUBMITTER: Berner C 

PROVIDER: S-EPMC8178455 | biostudies-literature | 2021 May-Jun

REPOSITORIES: biostudies-literature