DNA methylome analysis identifies BMI-related epigenetic changes associated with non-small cell lung cancer susceptibility.

ABSTRACT:

Background

Body mass index (BMI) has been reported to be inversely associated with incident risk of non-small cell lung cancer (NSCLC). However, the underlying mechanism is still unclear. This study aimed to investigate the role of DNA methylation in the relationship between BMI and NSCLC.

Methods

We carried out a genome-wide DNA methylation study of BMI in peripheral blood among 2266 Chinese participants by using Illumina Methylation arrays. For the BMI-related DNA methylation changes, their associations with NSCLC risk were further analyzed and their mediation effects on BMI-NSCLC association were also evaluated.

Results

The methylation levels of four CpGs (cg12593793, cg17061862, cg11024682, and cg06500161, annotated to LMNA, ZNF143, SREBF1, and ABCG1, respectively

SUBMITTER: Li G 

PROVIDER: S-EPMC8178488 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature