Associations between hepatitis B virus exposure and the risk of extrahepatic digestive system cancers: A hospital-based, case-control study (SIGES).

ABSTRACT:

Objectives

This case-control study was aimed to investigate associations between HBV infection and extrahepatic digestive system cancers.

Methods

The patients of gastric, small intestinal, colonic, rectal, anal, biliary tract, and pancreatic cancers were retrospectively collected between 2016.5 and 2017.12. Simultaneously, the healthy controls were collected from the health check-up registry, and cancer-free status was confirmed based on medical records. Propensity score matching was performed to reduce bias. Multinomial logit model and conditional logistic regression model were used to assess the risk of individual cancer according to HBV serological markers and classifications.

Results

Totally, 4748 patients involving seven cancers, and 57,499 controls were included

SUBMITTER: Wang H 

PROVIDER: S-EPMC8178500 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature