Identification of inhibitory immune checkpoints and relevant regulatory pathways in breast cancer stem cells.

ABSTRACT: Immune checkpoint blockade (ICB) has become one of the most promising approaches to activating antitumor immunity. However, only a small subset of patients with breast cancer benefit from ICB treatment. To improve the therapeutic effect in the clinic, precision immunotherapy is proposed to accurately eliminate cancer stem cells that contribute to local recurrence or metastasis, but currently little is known about their immunological properties. In this study, breast cancer-specific datasets in The Cancer Genome Atlas were collected and analyzed by using multiple open-access web servers. We found that the immunophenotype of breast cancer was characterized by a hypoactive immune microenvironment and a low response to immune checkpoint blockade. The innate immune checkpoint CD200 and the adap

SUBMITTER: Shi H 

PROVIDER: S-EPMC8178503 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature