Therapeutic potential of dental pulp stem cell transplantation in a rat model of Alzheimer's disease.

ABSTRACT: Dental pulp stem cells are dental pulp-derived mesenchymal stem cells that originate from the neural crest. They exhibit greater potential for the treatment of nervous system diseases than other types of stem cells because of their neurogenic differentiation capability and their ability to secrete multiple neurotrophic factors. Few studies have reported Alzheimer's disease treatment using dental pulp stem cells. Rat models of Alzheimer's disease were established by injecting amyloid-β1-42 into the hippocampus. Fourteen days later, 5 × 10⁶ dental pulp stem cells were injected into the hippocampus. Immunohistochemistry and western blot assays showed that dental pulp stem cell transplantation increased the expression of neuron-related doublecortin, NeuN, and neurofilament 200 in th

SUBMITTER: Zhang XM 

PROVIDER: S-EPMC8178760 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature