Bioinformatic analysis of cytokine expression in the proximal and distal nerve stumps after peripheral nerve injury.

ABSTRACT: In our previous study, we investigated the dynamic expression of cytokines in the distal nerve stumps after peripheral nerve injury using microarray analysis, which can characterize the dynamic expression of proteins. In the present study, we used a rat model of right sciatic nerve transection to examine changes in the expression of cytokines at 1, 7, 14 and 28 days after injury using protein microarray analysis. Interleukins were increased in the distal nerve stumps at 1-14 days post nerve transection. However, growth factors and growth factor-related proteins were mainly upregulated in the proximal nerve stumps. The P-values of the inflammatory response, apoptotic response and cell-cell adhesion in the distal stumps were higher than those in the proximal nerve stumps, but the opposite wa

SUBMITTER: Cheng XQ 

PROVIDER: S-EPMC8178785 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature