The effect of revascularization on recovery of mitochondrial respiration in peripheral artery disease: a case control study.

ABSTRACT:

Background

Peripheral arterial disease (PAD) is accompanied by myopathy characterized by mitochondrial dysfunction. The aim of this experimental study was to investigate the effect of revascularization procedures on mitochondrial function in ischemic and non-ischemic muscle.

Methods

Muscle biopsies from patients with symptomatic stage IIB/III PAD caused by isolated pathologies of the superficial femoral artery were obtained from muscle regions within the chronic ischemic muscle (gastrocnemius) and from non-ischemic muscle (vastus lateralis) before and 6 weeks after invasive revascularization. High-resolution respirometry was used to investigate mitochondrial function and results were normalized to citrate synthase activity (CSA). Results are given in absolute values and fold

SUBMITTER: Gratl A 

PROVIDER: S-EPMC8178834 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature