Cellular dormancy in minimal residual disease following targeted therapy.

ABSTRACT:

Background

Breast cancer mortality is principally due to tumor recurrence, which can occur following extended periods of clinical remission that may last decades. While clinical latency has been postulated to reflect the ability of residual tumor cells to persist in a dormant state, this hypothesis remains unproven since little is known about the biology of these cells. Consequently, defining the properties of residual tumor cells is an essential goal with important clinical implications for preventing recurrence and improving cancer outcomes.

Methods

To identify conserved features of residual tumor cells, we modeled minimal residual disease using inducible transgenic mouse models for HER2/neu and Wnt1-driven tumorigenesis that recapitulate cardinal features of human breast

SUBMITTER: Ruth JR 

PROVIDER: S-EPMC8178846 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature