SnoRNA copy regulation affects family size, genomic location and family abundance levels.

ABSTRACT:

Background

Small nucleolar RNAs (snoRNAs) are an abundant class of noncoding RNAs present in all eukaryotes and best known for their involvement in ribosome biogenesis. In mammalian genomes, many snoRNAs exist in multiple copies, resulting from recombination and retrotransposition from an ancestral snoRNA. To gain insight into snoRNA copy regulation, we used Rfam classification and normal human tissue expression datasets generated using low structure bias RNA-seq to characterize snoRNA families.

Results

We found that although box H/ACA families are on average larger than box C/D families, the number of expressed members is similar for both types. Family members can cover a wide range of average abundance values, but importantly, expression variability of individual members o

SUBMITTER: Bergeron D 

PROVIDER: S-EPMC8178906 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature