Preclinical models as patients' avatars for precision medicine in colorectal cancer: past and future challenges.

ABSTRACT: Colorectal cancer (CRC) is a complex and heterogeneous disease, characterized by dismal prognosis and low survival rate in the advanced (metastatic) stage. During the last decade, the establishment of novel preclinical models, leading to the generation of translational discovery and validation platforms, has opened up a new scenario for the clinical practice of CRC patients. To bridge the results developed at the bench with the medical decision process, the ideal model should be easily scalable, reliable to predict treatment responses, and flexibly adapted for various applications in the research. As such, the improved benefit of novel therapies being tested initially on valuable and reproducible preclinical models would lie in personalized treatment recommendations based on the biology an

SUBMITTER: Durinikova E 

PROVIDER: S-EPMC8178911 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature