The site-selectivity and mechanism of Pd-catalyzed C(sp²)-H arylation of simple arenes.

ABSTRACT: Control over site-selectivity is a critical challenge for practical application of catalytic C-H functionalization reactions in organic synthesis. Despite the seminal breakthrough of the Pd-catalyzed C(sp²)-H arylation of simple arenes via a concerted metalation-deprotonation (CMD) pathway in 2006, understanding the site-selectivity of the reaction still remains elusive. Here, we have comprehensively investigated the scope, site-selectivity, and mechanism of the Pd-catalyzed direct C-H arylation reaction of simple arenes. Counterintuitively, electron-rich arenes preferably undergo meta-arylation without the need for a specifically designed directing group, whereas electron-deficient arenes bearing fluoro or cyano groups exhibit high ortho-selectivity and ele

SUBMITTER: Kim D 

PROVIDER: S-EPMC8178950 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature