Redox responsive activity regulation in exceptionally stable supramolecular assembly and co-assembly of a protein.

ABSTRACT: Supramolecular assembly of biomolecules/macromolecules stems from the desire to mimic complex biological structures and functions of living organisms. While DNA nanotechnology is already in an advanced stage, protein assembly is still in its infancy as it is a significantly difficult task due to their large molecular weight, conformational complexity and structural instability towards variation in temperature, pH or ionic strength. This article reports highly stable redox-responsive supramolecular assembly of a protein Bovine serum albumin (BSA) which is functionalized with a supramolecular structure directing unit (SSDU). The SSDU consists of a benzamide functionalized naphthalene-diimide (NDI) chromophore which is attached with the protein by a bio-reducible disulfide linker. The SSDU at

SUBMITTER: Chakraborty S 

PROVIDER: S-EPMC8179030 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature