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Carbon monoxide and hydrogen (syngas) as a C1-building block for selective catalytic methylation.

ABSTRACT: A catalytic reaction using syngas (CO/H₂) as feedstock for the selective β-methylation of alcohols was developed whereby carbon monoxide acts as a C1 source and hydrogen gas as a reducing agent. The overall transformation occurs through an intricate network of metal-catalyzed and base-mediated reactions. The molecular complex [Mn(CO)₂Br[HN(C₂H₄P ⁱ Pr₂)₂]] 1 comprising earth-abundant manganese acts as the metal component in the catalytic system enabling the generation of formaldehyde from syngas in a synthetically useful reaction. This new syngas conversion opens pathways to install methyl branches at sp³ carbon centers utilizing renewable feedstocks and energy for the synthesis of biologically active compounds, fine chemicals, and advanced biofuels.

SUBMITTER: Kaithal A

PROVIDER: S-EPMC8179066 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Carbon monoxide and hydrogen (syngas) as a C1-building block for selective catalytic methylation.

Kaithal Akash A Hölscher Markus M Leitner Walter W

Chemical science 20201120 3

A catalytic reaction using syngas (CO/H2) as feedstock for the selective β-methylation of alcohols was developed whereby carbon monoxide acts as a C1 source and hydrogen gas as a reducing agent. The overall transformation occurs through an intricate network of metal-catalyzed and base-mediated reactions. The molecular complex [Mn(CO)2Br[HN(C2H4P i Pr2)2]] 1 comprising earth-abundant manganese acts as the m ...[more]

PMID: 34163864

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