Elucidating dissociation activation energies in host-guest assemblies featuring fast exchange dynamics.

ABSTRACT: The ability to mediate the kinetic properties and dissociation activation energies (E _a) of bound guests by controlling the characteristics of "supramolecular lids" in host-guest molecular systems is essential for both their design and performance. While the synthesis of such systems is well advanced, the experimental quantification of their kinetic parameters, particularly in systems experiencing fast association and dissociation dynamics, has been very difficult or impossible with the established methods at hand. Here, we demonstrate the utility of the NMR-based guest exchange saturation transfer (GEST) approach for quantifying the dissociation exchange rates (k _out) and activation energy (E _a,out) in host-guest systems featuring fast

SUBMITTER: Shusterman-Krush R 

PROVIDER: S-EPMC8179218 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature