Mechanochemical activation of disulfide-based multifunctional polymers for theranostic drug release.

ABSTRACT: Drug delivery systems responsive to physicochemical stimuli allow spatiotemporal control over drug activity to overcome limitations of systemic drug administration. Alongside, the non-invasive real-time tracking of drug release and uptake remains challenging as pharmacophore and reporter function are rarely unified within one molecule. Here, we present an ultrasound-responsive release system based on the mechanochemically induced 5-exo-trig cyclization upon scission of disulfides bearing cargo molecules attached via β-carbonate linker within the center of a water soluble polymer. In this bifunctional theranostic approach, we release one reporter molecule per drug molecule to quantitatively track drug release and distribution within the cell in real-time. We use N-butyl

SUBMITTER: Shi Z 

PROVIDER: S-EPMC8179261 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature