Short-chain reactive probes as tools to unravel the Pseudomonas aeruginosa quorum sensing regulon.

ABSTRACT: In recent years, the world has seen a troubling increase in antibiotic resistance among bacterial pathogens. In order to provide alternative strategies to combat bacterial infections, it is crucial deepen our understanding into the mechanisms that pathogens use to thrive in complex environments. Most bacteria use sophisticated chemical communication systems to sense their population density and coordinate gene expression in a collective manner, a process that is termed "quorum sensing" (QS). The human pathogen Pseudomonas aeruginosa uses several small molecules to regulate QS, and one of them is N-butyryl-l-homoserine lactone (C₄-HSL). Using an activity-based protein profiling (ABPP) strategy, we designed biomimetic probes with a photoreactive group and a 'click' t

SUBMITTER: Yashkin A 

PROVIDER: S-EPMC8179429 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature