Photoredox catalysis on unactivated substrates with strongly reducing iridium photosensitizers.

ABSTRACT: Photoredox catalysis has emerged as a powerful strategy in synthetic organic chemistry, but substrates that are difficult to reduce either require complex reaction conditions or are not amenable at all to photoredox transformations. In this work, we show that strong bis-cyclometalated iridium photoreductants with electron-rich β-diketiminate (NacNac) ancillary ligands enable high-yielding photoredox transformations of challenging substrates with very simple reaction conditions that require only a single sacrificial reagent. Using blue or green visible-light activation we demonstrate a variety of reactions, which include hydrodehalogenation, cyclization, intramolecular radical addition, and prenylation via radical-mediated pathways, with optimized conditions that only require the pho

SUBMITTER: Shon JH 

PROVIDER: S-EPMC8179447 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature