Sepsis in the era of data-driven medicine: personalizing risks, diagnoses, treatments and prognoses.

ABSTRACT: Sepsis is a series of clinical syndromes caused by the immunological response to infection. The clinical evidence for sepsis could typically attribute to bacterial infection or bacterial endotoxins, but infections due to viruses, fungi or parasites could also lead to sepsis. Regardless of the etiology, rapid clinical deterioration, prolonged stay in intensive care units and high risk for mortality correlate with the incidence of sepsis. Despite its prevalence and morbidity, improvement in sepsis outcomes has remained limited. In this comprehensive review, we summarize the current landscape of risk estimation, diagnosis, treatment and prognosis strategies in the setting of sepsis and discuss future challenges. We argue that the advent of modern technologies such as in-depth molecular profil

SUBMITTER: Liu AC 

PROVIDER: S-EPMC8179509 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature