Coloring ultrasensitive MRI with tunable metal-organic frameworks.

ABSTRACT: As one of the most important imaging modalities, magnetic resonance imaging (MRI) still faces relatively low sensitivity to monitor low-abundance molecules. A newly developed technology, hyperpolarized ¹²⁹Xe magnetic resonance imaging (MRI), can boost the signal sensitivity to over 10 000-fold compared with that under conventional MRI conditions, and this technique is referred to as ultrasensitive MRI. However, there are few methods to visualize complex mixtures in this field due to the difficulty in achieving favorable "cages" to capture the signal source, namely, ¹²⁹Xe atoms. Here, we proposed metal-organic frameworks (MOFs) as tunable nanoporous hosts to provide suitable cavities for xenon. Due to the widely dispersed spectroscopic signals, ¹²⁹Xe in diff

SUBMITTER: Yang Y 

PROVIDER: S-EPMC8179523 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature