Nickel-catalyzed asymmetric reductive arylation of α-chlorosulfones with aryl halides.

ABSTRACT: We report an asymmetric Ni-catalyzed reductive cross-coupling of aryl/heteroaryl halides with racemic α-chlorosulfones to afford enantioenriched sulfones. The reaction tolerates a variety of functional groups under mild reaction conditions, which complements the current methods. The utility of this work was demonstrated by facile late-stage functionalization of commercial drugs.

SUBMITTER: Sun D 

PROVIDER: S-EPMC8179603 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature