Programmed catalysis within stimuli-responsive mechanically unlocked nanocavities in DNA origami tiles.

ABSTRACT: The assembly of reversible stimuli-responsive locked DNA origami tiles being unlocked, in the presence of appropriate triggers, to form nanocavities in the origami rafts, is introduced. In the presence of ATP, K⁺-ion-stabilized G-quadruplexes or pH-responsive T-A·T triggers and appropriately engineered "helper units", the origami rafts are unlocked to form nanocavities. By the application of appropriate counter-triggers, the nanocavities are relocked, thus establishing the switchable and reversible "mechanical" opening and closure mechanism of the nanocavities. The interconnection of the stimuli-responsive origami tiles into dimer structures enables the programmed triggered unlocking of each of the origami tiles, or both of the origami tiles, to yield dictated nanocavity-contain

SUBMITTER: Wang J 

PROVIDER: S-EPMC8179671 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature