Identification of an Alveolar Macrophage-Related Core Gene Set in Acute Respiratory Distress Syndrome.

ABSTRACT:

Purpose

Acute respiratory distress syndrome (ARDS) is a rapidly progressive diffuse lung injury that is characterized by high mortality and acute onset. The pathological mechanisms of ARDS are still unclear. But alveolar macrophages have been shown to play an important role in inflammatory responses during ARDS. We aimed to find the biomarkers for ARDS for early diagnosis, to give ARDS patients timely treatment.

Methods

Gene expression profiles were downloaded from Gene Expression Omnibus (GEO) and screened for differentially expressed genes (DEGs). The common upregulated genes in all the datasets were defined as circulating ARDS alveolar macrophage-related genes (cARDSAMGs). We performed a functional enrichment analysis to explore potential biological functions of cARDSAMGs

SUBMITTER: Zhao C 

PROVIDER: S-EPMC8179830 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature