Decreased inflammatory cytokine production of antigen-specific CD4⁺ T cells in NMDA receptor encephalitis.

ABSTRACT: Anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis is the most common autoimmune encephalitis with psychosis, amnesia, seizures and dyskinesias. The disease is mediated by pathogenic autoantibodies against the NR1 subunit that disrupt NMDAR function. Antibody infusion into mouse brains can recapitulate encephalitis symptoms, while active immunization resulted also in strong T cell infiltration into the hippocampus. However, whether T cells react against NMDAR and their specific contribution to disease development are poorly understood. Here we characterized the ex vivo frequency and phenotype of circulating CD4⁺ T helper (T_H) cells reactive to NR1 protein using antigen-reactive T cell enrichment (ARTE) in 24 patients with NMDAR encephalitis, 13 patients with LGI1

SUBMITTER: Dao LM 

PROVIDER: S-EPMC8179900 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature