Maternal genetics influences fetal neurodevelopment and postnatal autism spectrum disorder-like phenotype by modulating in-utero immunosuppression.

ABSTRACT: Genetic studies in ASD have mostly focused on the proband, with no clear understanding of parental genetic contributions to fetal neurodevelopment. Among parental etiological factors, perinatal maternal inflammation secondary to autoimmunity, infections, and toxins is associated with ASD. However, the inherent impact of maternal genetics on in-utero inflammation and fetal neurodevelopment in the absence of strong external inflammatory exposures is not known. We used the Pten^WT/m3m4 mouse model for ASD to demonstrate the impact of maternal genetics on the penetrance of ASD-like phenotypes in the offspring. Pten^WT/m3m4 (Mom^m3m4) or Pten^WT/WT (Mom^WT) females, their offspring, and placental interface were analyzed for inflammatory markers,

SUBMITTER: Jaini R 

PROVIDER: S-EPMC8179926 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature