Consequences of mutation accumulation for growth performance are more likely to be resource-dependent at higher temperatures.

ABSTRACT:

Background

Mutation accumulation (MA) has profound ecological and evolutionary consequences. One example is that accumulation of conditionally neutral mutations leads to fitness trade-offs among heterogenous habitats which cause population divergence. Here we suggest that temperature, which controls the rates of all biochemical and biophysical processes, should play a crucial role for determining mutational effects. Particularly, warmer temperatures may mitigate the effects of some, not all, deleterious mutations and cause stronger environmental dependence in MA effects.

Results

We experimentally tested the above hypothesis by measuring the growth performance of ten Escherichia coli genotypes on six carbon resources across ten temperatures, where the ten genotypes were deriv

SUBMITTER: Chu XL 

PROVIDER: S-EPMC8180013 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature