Genome-wide association studies reveal candidate genes associated to bacteraemia caused by ST93-IV CA-MRSA.

ABSTRACT:

Background

The global emergence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) has seen the dominance of specific clones in different regions around the world with the PVL-positive ST93-IV as the predominant CA-MRSA clone in Australia. In this study we applied a genome-wide association study (GWAS) approach on a collection of Australian ST93-IV MRSA genomes to screen for genetic traits that might have assisted the ongoing transmission of ST93-IV in Australia. We also compared the genomes of ST93-IV bacteraemia and non-bacteraemia isolates to search for potential virulence genes associated with bacteraemia.

Results

Based on single nucleotide polymorphism phylogenetics we revealed two distinct ST93-IV clades circulating concurrently in Australia.

SUBMITTER: Pang S 

PROVIDER: S-EPMC8180019 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature