The Causal Relationship Between Body Mass Index and the Risk of Osteoarthritis.

ABSTRACT:

Objective

The study aimed to explore the causal effect of body mass index (BMI) on osteoarthritis.

Methods

The genome-wide association data of BMI and osteoarthritis were obtained via the Mendelian randomization (MR)-base platform. Single nucleotide polymorphisms (SNPs) significantly associated with BMI were identified and used as instrumental variables, and the causal relationship between BMI and osteoarthritis was examined using the two-sample MR research method. Three statistical methods including inverse-variance weighted (IVW) method, weighted median estimator, and MR-Egger regression were employed.

Results

A total of 79 SNPs significantly associated with BMI were identified in the study (P<5×10^-8; linkage disequilibrium r² <0.1). Consistent

SUBMITTER: He Y 

PROVIDER: S-EPMC8180293 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature