Endothelial β1 Integrin-Mediated Adaptation to Myocardial Ischemia.

ABSTRACT:

Background

 Short episodes of myocardial ischemia can protect from myocardial infarction. However, the role of endothelial β1 integrin in these cardioprotective ischemic events is largely unknown.

Objective

 In this study we investigated whether endothelial β1 integrin is required for cardiac adaptation to ischemia and protection from myocardial infarction.

Methods

 Here we introduced transient and permanent left anterior descending artery (LAD) occlusions in mice. We inhibited β1 integrin by intravenous injection of function-blocking antibodies and tamoxifen-induced endothelial cell (EC)-specific deletion of Itgb1. Furthermore, human ITGB1 was silenced in primary human coronary artery ECs using small interfering RNA. We analyzed the numbers of prolifera

SUBMITTER: Henning C 

PROVIDER: S-EPMC8180378 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature