Osteoconductive properties of upside-down bilayer collagen membranes in rat calvarial defects.

ABSTRACT:

Background

Bilayer collagen membranes are routinely used in guided bone/tissue regeneration to serve as osteoconductive scaffolds and prevent the invasion of soft tissues. It is recommended to place the membranes with their dense layer towards the soft tissue and their porous layer towards the bony defect area. However, evidence supporting this recommendation is lacking. This study aimed to determine whether the alignment of bilayer collagen membranes has an effect on bone regeneration.

Methods

In two groups of ten male Sprague-Dawley rats each, a 5-mm calvarial defect was created. Thereafter, the defect was randomly covered with a bilayer, resorbable, pure type I and III collagen membrane placed either regularly or upside-down (i.e., dense layer towards bone defect). After

SUBMITTER: Feher B 

PROVIDER: S-EPMC8180471 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature