Cochlin Deficiency Protects Against Noise-Induced Hearing Loss.

ABSTRACT: Cochlin is the most abundant protein in the inner ear. To study its function in response to noise trauma, we exposed adolescent wild-type (Coch ^+/+ ) and cochlin knock-out (Coch ^-/-) mice to noise (8-16 kHz, 103 dB SPL, 2 h) that causes a permanent threshold shift and hair cell loss. Two weeks after noise exposure, Coch^-/- mice had substantially less elevation in noise-induced auditory thresholds and hair cell loss than Coch ^{+ / +} mice, consistent with cochlin deficiency providing protection from noise trauma. Comparison of pre-noise exposure thresholds of auditory brain stem responses (ABRs) and distortion product otoacoustic emissions (DPOAEs) in Coch^-/- mice and

SUBMITTER: Seist R 

PROVIDER: S-EPMC8180578 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature